Which condition involves chronic diarrhea and fatigue in infants?

• A. Andersen's disease
• B. DiGeorge's syndrome
• C. Wilson's disease
• D. Pneumococcal meningitis

Answer: (A)

Andersen's disease, also known as glycogen storage disease type 0, is a metabolic disorder that can manifest in infants with symptoms such as chronic diarrhea and fatigue. This condition arises from a deficiency in enzymes that are responsible for glycogen metabolism, leading to an inability to appropriately store and utilize glycogen. In infants especially, this can result in gastrointestinal issues, such as diarrhea, and a general lack of energy, contributing to fatigue.

The other conditions listed do not primarily present with these specific symptoms in infants. DiGeorge's syndrome is associated with immunodeficiencies and developmental delays; Wilson's disease pertains to copper metabolism issues leading to liver and neurological symptoms; and pneumococcal meningitis primarily presents with central nervous system symptoms like fever, neck stiffness, and altered mental status rather than chronic gastrointestinal disturbances.